Antibiotic A-23187 | Ca2+ ionophore

CAS:
52665-69-7
Catalog Number:
10-2284
Activity:
Ca2+ ionophore
Alternate Names:
Calcimycin
Molecular Weight:
523.62
Molecular Formula:
C29H37N3O6
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$70.00
25 mg$215.00

Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative phosphorylation.2 In addition, antibiotic A-23187 inhibits ATPase activity.3

References/Citations:

1) Reed and Lardy (1972) A23187: a divalent cation ionophore; J. Biol. Chem, 247 6970
2) Wong et al. (1973) Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria; Arch. Biochem. Biophys, 156 578
3) Hara and Kanazawa (1986) Selective inhibition by ionophore A23187 of the enzyme isomerization in the catalytic cycle of sarcoplasmic reticulum Ca2+-ATPase; J. Biol. Chem., 261 16584

CAS:
52665-69-7
Catalog Number:
10-2284
Activity:
Ca2+ ionophore
Alternate Names:
Calcimycin
Molecular Weight:
523.62
Molecular Formula:
C29H37N3O6
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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