Antimycin A | Mitochondrial Complex III inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 10mg | $50.00 | ||
| 50mg | $130.00 |
Antimycin A (1397-94-0) is a mitochondrial electron transport inhibitor at complex III. Induces apoptosis in various cell lines.1 Antimycin A may be used to generate cellular models of degenerative disorders by blocking the mitochondrial electron transport chain, disrupting energy metabolism, and elevating ROS levels.2-4 Induces canonical PINK1-Parkin-dependent mitophagy in Parkin overexpressing cells upon cotreatment with oligomycin.5
References/Citations:
- Muller et al. (2003), Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production; Biochemistry, 42 6493
- Choi et al. (2012), Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function; Inflammation, 35 1204
- Smith et al. (2023), Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated Na+ Channel Isoforms; J. Neurosci, 43 2291
- Barzegari et al. (2022), The protective effect of N-acetylcysteine on antimycin A-induced respiratory chain deficiency in mesenchymal stem cells; Chem. Biol. Interact., 360 109937
- Zachari et al. (2019), Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform; Dev. Cell, 50 627
C28H40N2O9
>97% TLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Antimycin A (1397-94-0) is a mitochondrial electron transport inhibitor at complex III. Induces apoptosis in various cell lines.1 Antimycin A may be used to generate cellular models of degenerative disorders by blocking the mitochondrial electron transport chain, disrupting energy metabolism, and elevating ROS levels.2-4 Induces canonical PINK1-Parkin-dependent mitophagy in Parkin overexpressing cells upon cotreatment with oligomycin.5
References/Citations:
- Muller et al. (2003), Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production; Biochemistry, 42 6493
- Choi et al. (2012), Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function; Inflammation, 35 1204
- Smith et al. (2023), Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated Na+ Channel Isoforms; J. Neurosci, 43 2291
- Barzegari et al. (2022), The protective effect of N-acetylcysteine on antimycin A-induced respiratory chain deficiency in mesenchymal stem cells; Chem. Biol. Interact., 360 109937
- Zachari et al. (2019), Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform; Dev. Cell, 50 627
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1-855-FOCUS21
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