AOH1996 | PCNA inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $250.00 |
AOH1996 (2089314-64-5) inhibits proliferating cell nuclear antigen (PCNA), an enzyme critical to DNA replication and repair processes.1 It enhances the interaction between PCNA and RPB1 subunit of RNA polymerase II leading to degradation of RPB1 and collapse of DNA replication forks in transcribed chromatin regions, thus increasing transcription replication stress causing genomic instability and lethal DNA damage. AOH1996 alone or in combination with topoisomerase inhibitor CPT-11 significantly reduced tumor burden in mice with xenograft tumors (neuroblastoma, breast, or small cell lung cancers) with no side effects. Orally bioavailable.
References/Citations:
- Gu et al. (2023), Small molecule targeting of transcription-replication conflict for selective chemotherapy; Cell Chem. Biol. 30 1235
C26H22N2O4
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AOH1996 (2089314-64-5) inhibits proliferating cell nuclear antigen (PCNA), an enzyme critical to DNA replication and repair processes.1 It enhances the interaction between PCNA and RPB1 subunit of RNA polymerase II leading to degradation of RPB1 and collapse of DNA replication forks in transcribed chromatin regions, thus increasing transcription replication stress causing genomic instability and lethal DNA damage. AOH1996 alone or in combination with topoisomerase inhibitor CPT-11 significantly reduced tumor burden in mice with xenograft tumors (neuroblastoma, breast, or small cell lung cancers) with no side effects. Orally bioavailable.
References/Citations:
- Gu et al. (2023), Small molecule targeting of transcription-replication conflict for selective chemotherapy; Cell Chem. Biol. 30 1235
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