AP-18 | TRPA1 blocker
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $70.00 | ||
| 50 mg | $280.00 |
AP-18 (55224-94-7) is a TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 μM.1 Blocks TRPA1 pore dilation (IC50=10.3 μM).2 An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.3-5
References”Citations:
- Petrus et al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40
- Chen et al. (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels; Mol. Pain, 5 3
- Lieder et al. (2017) The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes; Front. Pharmacol., 8 316
- Chepurny et al. (2016) GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion; Mol. Endocrinol., 30 614
- Cheah et al. (2014) Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism; Biochem. Pharmacol., 89 148
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AP-18 (55224-94-7) is a TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 μM.1 Blocks TRPA1 pore dilation (IC50=10.3 μM).2 An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.3-5
References”Citations:
- Petrus et al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40
- Chen et al. (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels; Mol. Pain, 5 3
- Lieder et al. (2017) The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes; Front. Pharmacol., 8 316
- Chepurny et al. (2016) GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion; Mol. Endocrinol., 30 614
- Cheah et al. (2014) Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism; Biochem. Pharmacol., 89 148
Related products
-
Gaboxadol HCl | GABA-A receptor agonist
From $60.00CAS:85118-33-8Catalog Number:10-1168Activity:GABA-A receptor agonistAlternate Names:THIP HClChemical Name:4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridine-3-ol hydrochlorideMolecular Weight:176.6Molecular Formula:C6H8N2O2 HClSolubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT -
E-4031 | hERG channel blocker
From $50.00CAS:113558-89-7Catalog Number:10-1213Activity:hERG channel blockerChemical Name:N-[4-[[1-[2-(6-Methyl-3-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride dihydrateMolecular Weight:510.47Molecular Formula:C21H27N3O3S·2HCl·2H2OSolubility:Soluble in DMSO (up to 25 mg/ml) or in Water (up to 100 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.Shipping Code:RT -
A-967079 | TRPA1 blocker
From $50.00CAS:1170613-55-4Catalog Number:10-1055Activity:TRPA1 blockerChemical Name:(1E,3E)-1-(4-Fluorophenyl)-2-methylpent-1-en-3-one oximeMolecular Weight:207.25Molecular Formula:C12H14FNOSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 monthsShipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
