AP-18 | TRPA1 blocker
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $70.00 | ||
| 50 mg | $280.00 |
AP-18 (55224-94-7) is a TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 μM.1 Blocks TRPA1 pore dilation (IC50=10.3 μM).2 An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.3-5
References”Citations:
- Petrus et al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40
- Chen et al. (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels; Mol. Pain, 5 3
- Lieder et al. (2017) The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes; Front. Pharmacol., 8 316
- Chepurny et al. (2016) GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion; Mol. Endocrinol., 30 614
- Cheah et al. (2014) Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism; Biochem. Pharmacol., 89 148
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AP-18 (55224-94-7) is a TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 μM.1 Blocks TRPA1 pore dilation (IC50=10.3 μM).2 An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.3-5
References”Citations:
- Petrus et al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40
- Chen et al. (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels; Mol. Pain, 5 3
- Lieder et al. (2017) The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes; Front. Pharmacol., 8 316
- Chepurny et al. (2016) GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion; Mol. Endocrinol., 30 614
- Cheah et al. (2014) Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism; Biochem. Pharmacol., 89 148
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