AP39 | Mitochondrial-targeted hydrogen sulfide donor
CAS:
1429173-57-8
Catalog Number:
10-3916
Activity:
Mitochondrial targeted hydrogen sulfide donor
Chemical Names:
(10-Oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide
Molecular Weight:
721.77
Molecular Formula:
C37H38BrO2PS3
Solubility:
Soluble in DMSO (at least 35 mg/ml)
Physical Properties:
Orange solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Hygroscopic! Protect from moisture and air.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $110.00 | ||
| 25 mg | $425.00 |
AP39 (1429173-57-8) is a mitochondrially targeted hydrogen sulfide donor. At lower concentrations (30 -100 nM), it acts as an electron donor and stimulator of mitochondrial electron transport and ATP production. AP39 displayed antioxidant and cytoprotective effects in oxidatively stressed endothelial cells.1 It displayed protective effects in various pathological states including renal injury2,3, Alzheimer’s4, ischemia5, and reperfusion injury6. Improves outcomes in subnormothermic organ preservation models.7,8
References/Citations:
- Szczesny et al. (2014), AP39, a hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro; Nitric Oxide, 41 120
- Ahmad et al. (2016), AP39, a Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects In Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo; Shock, 45 88
- Cao et al. (2018), Renal Protective Effect of Hydrogen Sulfide in Cisplatin-Induced Nephrotoxicity Redox Signal., 29 455
- Zhao et al. (2016), AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons; Oxid. Med. Cell. Longev., 2016 8360738
- Pomierny et al. (2021), The Slow-Releasing and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery Molecule AP39 Induces Brain Tolerance to Ischemia; Int. J. Mol. Sci., 22 7816
- Karwi et al. (2017), AP39, a mitochondria-targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signaling; Br. J. Pharmacol., 174 287
- Juriasingani et al. (2018), H2S supplementation: A novel method for successful organ preservation at subnormothermic temperatures; Nitric Oxide, 81 57
- Juriasingani et al. (2021), Subnormothermic Perfusion with H2S Donor AP39 Improves DCD Porcine Renal Graft Outcomes in an Ex Vivo Model of Kidney Preservation and Reperfusion; Biomolecules, 11 446
CAS:
1429173-57-8
Catalog Number:
10-3916
Activity:
Mitochondrial targeted hydrogen sulfide donor
Chemical Names:
(10-Oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide
Molecular Weight:
721.77
Molecular Formula:
C37H38BrO2PS3
Solubility:
Soluble in DMSO (at least 35 mg/ml)
Physical Properties:
Orange solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Hygroscopic! Protect from moisture and air.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AP39 (1429173-57-8) is a mitochondrially targeted hydrogen sulfide donor. At lower concentrations (30 -100 nM), it acts as an electron donor and stimulator of mitochondrial electron transport and ATP production. AP39 displayed antioxidant and cytoprotective effects in oxidatively stressed endothelial cells.1 It displayed protective effects in various pathological states including renal injury2,3, Alzheimer’s4, ischemia5, and reperfusion injury6. Improves outcomes in subnormothermic organ preservation models.7,8
References/Citations:
- Szczesny et al. (2014), AP39, a hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro; Nitric Oxide, 41 120
- Ahmad et al. (2016), AP39, a Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects In Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo; Shock, 45 88
- Cao et al. (2018), Renal Protective Effect of Hydrogen Sulfide in Cisplatin-Induced Nephrotoxicity Redox Signal., 29 455
- Zhao et al. (2016), AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons; Oxid. Med. Cell. Longev., 2016 8360738
- Pomierny et al. (2021), The Slow-Releasing and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery Molecule AP39 Induces Brain Tolerance to Ischemia; Int. J. Mol. Sci., 22 7816
- Karwi et al. (2017), AP39, a mitochondria-targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signaling; Br. J. Pharmacol., 174 287
- Juriasingani et al. (2018), H2S supplementation: A novel method for successful organ preservation at subnormothermic temperatures; Nitric Oxide, 81 57
- Juriasingani et al. (2021), Subnormothermic Perfusion with H2S Donor AP39 Improves DCD Porcine Renal Graft Outcomes in an Ex Vivo Model of Kidney Preservation and Reperfusion; Biomolecules, 11 446
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