Apicidin | HDAC inhibitor

CAS:
183506-66-3
Catalog Number:
10-2057
Activity:
HDAC inhibitor
Chemical Name:
Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]
Molecular Weight:
623.78
Molecular Formula:
C34H49N5O6
Solubility:
Soluble in DMSO (up to 1 mg/ml)
Physical Properties:
White solid
Purity:
>98%
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. Compound is prone to oxidation. Protect from exposure to air.
Shipping Code:
RT

Available Options

size :PriceQuantity 
1 mg$55.00
5 mg$220.00

Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC’s).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression causing cell cycle arrest in the G1 phase.2 Apicidin dramatically decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines.3

References/Citations:

1) Darkin-Rattray, et al. (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase; Proc. Nat. Acad. Sci. USA, 93 13143
2) Han et al. (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin; Cancer Res., 60 6068
3) Kim et al. (2007) Regulation of the HIF-1alpha stability by histone deacetylases; Oncol. Rep. 17 647

CAS:
183506-66-3
Catalog Number:
10-2057
Activity:
HDAC inhibitor
Chemical Name:
Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]
Molecular Weight:
623.78
Molecular Formula:
C34H49N5O6
Solubility:
Soluble in DMSO (up to 1 mg/ml)
Physical Properties:
White solid
Purity:
>98%
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. Compound is prone to oxidation. Protect from exposure to air.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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