size : | Price | Quantity | |
---|---|---|---|
10 mg | $36.00 | ||
50 mg | $130.00 |
Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of cellular proliferation via G2/M cell cycle arrest3,5, reduction of HIF-1 and VEGF expression6, and inhibition of nitric oxide and PGE2 synthesis7.
References/Citations:
1) Lin et al. (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin; J. Cell. Biochem. Suppl. 28-29 39
2) Zhao et al. (2011) Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90; Mol. Cancer, 10 10
3) Yin et al. (2001) Apigenin inhibits growth and induces G2/M arrest by modulating cyclinCDK regulators and ERK MAP kinase activation in breast carcinoma cells; Anticancer Research 21 413
4) Si et al. (2009) Mechanism of CYP2C9 inhibition by flavones and flavonols; Drug Metabolism and Disposition, 37 629
5) Sato et al. (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells; Biochem. Biophys. Res. Commun. 204 578
6) Fang et al. (2007) Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression; Carcinogenesis, 28 858
7) Raso et al. (2001) Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1; Life Sci., 68 921
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Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of cellular proliferation via G2/M cell cycle arrest3,5, reduction of HIF-1 and VEGF expression6, and inhibition of nitric oxide and PGE2 synthesis7.
References/Citations:
1) Lin et al. (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin; J. Cell. Biochem. Suppl. 28-29 39
2) Zhao et al. (2011) Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90; Mol. Cancer, 10 10
3) Yin et al. (2001) Apigenin inhibits growth and induces G2/M arrest by modulating cyclinCDK regulators and ERK MAP kinase activation in breast carcinoma cells; Anticancer Research 21 413
4) Si et al. (2009) Mechanism of CYP2C9 inhibition by flavones and flavonols; Drug Metabolism and Disposition, 37 629
5) Sato et al. (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells; Biochem. Biophys. Res. Commun. 204 578
6) Fang et al. (2007) Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression; Carcinogenesis, 28 858
7) Raso et al. (2001) Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1; Life Sci., 68 921
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