Aprepitant | NK-1 antagonist
CAS:
170729-80-3
Catalog Number:
10-4366
Activity:
NK-1 antagonist
Chemical Names:
3-[[(2R,3S)-2-[(1R)-1-bis(Trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4dihydro-1,2,4-triazol-5-one
Alternate Name:
MK-0869
Molecular Weight:
534.43
Molecular Formula:
C23H21F7N4O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $40.00 | ||
| 50 mg | $130.00 |
Aprepitant (170729-80-3) is a potent human neurokinin-1 (NK-1) antagonist.1 It is an FDA approved medication for the treatment of chemotherapy-induced and postoperative nausea and vomiting.2 Aprepitant is also a selective activator of the K2P channel TRAAK.3 It also has been shown to have multiple anticancer effects.4
References/Citations:
- Hale et al. (1998), Structural optimization affording 2-(R)-(1-(R)-3,5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1receptor antagonist; Med. Chem. 41 4607
- Rapoport and Smit (2017); Clinical pharmacology of neurokinin-1 receptor antagonists for the treatment of nausea and vomiting associated with chemotherapy, Expert Opin. Drug Saf., 16 697
- McCoull et al. (2022); Aprepitant is a novel, selective activator of the K2P channel TRAAK, Biochem. Biophys. Res. Commun., 588 41
- Muñoz and Coveñas (2020); The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer?, Cancer (Basel), 12 2682
CAS:
170729-80-3
Catalog Number:
10-4366
Activity:
NK-1 antagonist
Chemical Names:
3-[[(2R,3S)-2-[(1R)-1-bis(Trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4dihydro-1,2,4-triazol-5-one
Alternate Name:
MK-0869
Molecular Weight:
534.43
Molecular Formula:
C23H21F7N4O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Aprepitant (170729-80-3) is a potent human neurokinin-1 (NK-1) antagonist.1 It is an FDA approved medication for the treatment of chemotherapy-induced and postoperative nausea and vomiting.2 Aprepitant is also a selective activator of the K2P channel TRAAK.3 It also has been shown to have multiple anticancer effects.4
References/Citations:
- Hale et al. (1998), Structural optimization affording 2-(R)-(1-(R)-3,5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1receptor antagonist; Med. Chem. 41 4607
- Rapoport and Smit (2017); Clinical pharmacology of neurokinin-1 receptor antagonists for the treatment of nausea and vomiting associated with chemotherapy, Expert Opin. Drug Saf., 16 697
- McCoull et al. (2022); Aprepitant is a novel, selective activator of the K2P channel TRAAK, Biochem. Biophys. Res. Commun., 588 41
- Muñoz and Coveñas (2020); The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer?, Cancer (Basel), 12 2682
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