AqB013 | Aquaporin blocker
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $70.00 | ||
| 25mg | $280.00 |
AqB013 (1021869-51-1) is a selective aquaporin-1 and -4 inhibitor (IC50 ~ 20 mM) which acts at the cytoplasmic side of the AQP water pore.1 It blocks cGMP-stimulated human retinal pigment epithelium fluid transport.2 In HT29 colon cancer cells AqB013 restricted migration and invasiveness and prevented endothelial tube formation.3,4 It reduces the invasiveness of U87-MG and U251-MG glioblastoma cells in vitro.5
References/Citations:
- Migliati et al. (2009); Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site; Mol. Pharmacol., 76 105
- Baetz et al. (2012); Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro, Invest. Ophthalmol. Vis. Sci., 53 2127
- Dorward et al. (2016); Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro, J. Exp. Clin. Cancer Res., 35 36
- Tomita et al. (2019); Bumetanide-Derived Aquaporin 1 Inhibitors AqB013 and AqB050 Inhibit Tube Formation of Endothelial Cells through Induction of Apoptosis and Impaired Migration in Vitro, Int. J. Mol. Sci., 20 1818
- Varricchio et al. (2023); Pharmacological Inhibition of Membrane Signaling Mechanisms Reduces the Invasiveness of U87-MG and U251-MG Glioblastoma Cells In Vitro, Cancers (Basel), 15 1027
C22H24N4O4S
>98% TLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AqB013 (1021869-51-1) is a selective aquaporin-1 and -4 inhibitor (IC50 ~ 20 mM) which acts at the cytoplasmic side of the AQP water pore.1 It blocks cGMP-stimulated human retinal pigment epithelium fluid transport.2 In HT29 colon cancer cells AqB013 restricted migration and invasiveness and prevented endothelial tube formation.3,4 It reduces the invasiveness of U87-MG and U251-MG glioblastoma cells in vitro.5
References/Citations:
- Migliati et al. (2009); Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site; Mol. Pharmacol., 76 105
- Baetz et al. (2012); Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro, Invest. Ophthalmol. Vis. Sci., 53 2127
- Dorward et al. (2016); Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro, J. Exp. Clin. Cancer Res., 35 36
- Tomita et al. (2019); Bumetanide-Derived Aquaporin 1 Inhibitors AqB013 and AqB050 Inhibit Tube Formation of Endothelial Cells through Induction of Apoptosis and Impaired Migration in Vitro, Int. J. Mol. Sci., 20 1818
- Varricchio et al. (2023); Pharmacological Inhibition of Membrane Signaling Mechanisms Reduces the Invasiveness of U87-MG and U251-MG Glioblastoma Cells In Vitro, Cancers (Basel), 15 1027
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