AR-A 014418 | GSK-3 inhibitor

CAS:
487021-52-3
Catalog Number:
10-1195
Activity:
GSK-3 inhibitor
Chemical Name:
N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
Molecular Weight:
308.32
Molecular Formula:
C12H12N4O4S
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$50.00
25 mg$200.00
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AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable. Active in rodent models.

References/Citations:

1) Bhat et al. (2003), Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418; J. Biol. Chem., 278 45937
2) Ramirez et al. (2010), Inhibition of glycogen synthase kinase 3beta (GSK3β) decreases inflammatory responses in brain endothelial cells; Am. J. Pathol., 176 881

CAS:
487021-52-3
Catalog Number:
10-1195
Activity:
GSK-3 inhibitor
Chemical Name:
N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
Molecular Weight:
308.32
Molecular Formula:
C12H12N4O4S
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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