Argatroban | Thrombin inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $56.00 | ||
| 50 mg | $224.00 |
Argatroban (74863-84-6) is a potent and selective inhibitor of thrombin (Ki = 19 nM).1 Prevents platelet-rich arterial thrombosis in a rabbit model.2 Ameliorates early brain injury and improves neurological outcomes after subarachnoid hemorrhage in a rat model.3 Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and independent mechanisms.4
References/Citations:
1) Kikumoto et al. (1984), Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid; Biochemistry, 23 85
2) Jang et al. (1990), Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition; Circulation, 81 219
3) Sugawara et al. (2009), Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats; Stroke, 40 1530
4) Schulze et al. (2008), The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms; Breast Cancer Res. Treat., 112 243
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Argatroban (74863-84-6) is a potent and selective inhibitor of thrombin (Ki = 19 nM).1 Prevents platelet-rich arterial thrombosis in a rabbit model.2 Ameliorates early brain injury and improves neurological outcomes after subarachnoid hemorrhage in a rat model.3 Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and independent mechanisms.4
References/Citations:
1) Kikumoto et al. (1984), Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid; Biochemistry, 23 85
2) Jang et al. (1990), Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition; Circulation, 81 219
3) Sugawara et al. (2009), Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats; Stroke, 40 1530
4) Schulze et al. (2008), The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms; Breast Cancer Res. Treat., 112 243
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