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Argatroban | Thrombin inhibitor

Argatroban (74863-84-6) is a potent and selective inhibitor of thrombin (Ki = 19 nM)1. Prevents platelet-rich arterial thrombosis in a rabbit model2. Ameliorates early brain injury and improves neurological outcomes after subarachnoid hemorrhage in a rat model3. Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and independent mechanisms4.

References/Citations
1) Kikumoto et al. (1984), Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +)sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid; Biochemistry, 23 85
2) Jang et al. (1990), Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition; Circulation, 81 219
3) Sugawara et al. (2009), Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats; Stroke, 40 1530
4) Schulze et al. (2008), The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms; Breast Cancer Res. Treat., 112 243

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Argatroban | Thrombin inhibitor | CAS 74863-84-6

Catalog#  10-2809

$56.00
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CAS:
74863-84-6
Catalog Number:
10-2809
Activity:
Thrombin inhibitor
Alternate Names:
Argidipine; MQPA
Chemical Name:
(2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
Molecular Weight:
508.63
Molecular Formula:
C23H36N6O5S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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