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Artesunate | Kills cancer stem cells / Depolarizes mitochondria

Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of reactive oxygen species which disrupt the electron transport chain.1 Generation of mitochondrial ROS is dependent on RIP1.2 Inhibits TNFα-induced production of proinflammatory cytokines in human RA fibroblast-like synoviocytes.3 Displays cytotoxicity against a variety of cancer cells4 and cancer stem cells5.

References/Citations

1) Li et al. (2005), Yeast model uncovers dual roles of mitochondria in action of artemisinin; PLoS Genet., 1(3) e36
2) Chauhan et al. (2017), RIP1-dependent reactive oxygen species production executes artesunate-induced cell death in renal carcinoma Caki cells; Mol. Cell. Biochem., 435 15
3) Xu et al. (2007), Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/AKt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes; Rheumatology (Oxford), 46 920
4) Ghantous et al. (2010), What made sesquiterpene lactones reach cancer clinical trials?; Drug. Disc. Today, 15 668
5) Subedi et al. (2016), High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism; Biochem. Biophys. Res. Commun., 477 737

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Focus Biomolecules cell signaling reagent supplier, chemical structure Artesunate | Kills cancer stem cells | CAS 88495-63-0

Catalog#  10-2411-0100

$45.00
Quantity
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CAS:
88495-63-0
Catalog Number:
10-2411
Activity:
Kills cancer stem cells / Depolarizes mitochondria
Chemical Name:
Succinyl dihydroartemisinin
Molecular Weight:
384.42
Molecular Formula:
C19H28O8
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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