AG-1296 | PDGFR kinase inhibitor

AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC₅₀ = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells.

References/Citations
1) Kovalenko et al. (1997), Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296; Biochemistry, 36 6260
2) Krystal et al. (1997), Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins; Cancer Res., 57 220
3) Strutz et al. (2001), TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2); Kidney Int., 59 579