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Product Details

AG-1296 | PDGFR kinase inhibitor

AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells.

References/Citations
1) Kovalenko et al. (1997), Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296; Biochemistry, 36 6260
2) Krystal et al. (1997), Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins; Cancer Res., 57 220
3) Strutz et al. (2001), TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2); Kidney Int., 59 579

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Focus Biomolecules cell signaling reagent supplier, structure of AG-1296 | PDGFR kinase inhibitor | CAS 146535-11-7

Catalog#  10-1087

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
146535-11-7
Catalog Number:
10-1087
Activity:
PDGFR kinase inhibitor
Chemical Name:
6,7-Dimethoxy-3-phenylquinoxaline
Molecular Weight:
266.3
Molecular Formula:
C16H14N2O2
Solubility:
Soluble in DMSO.
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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