AS-605240 | PI3-Kinase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $190.00 |
AS-605240 (648450-29-7) is a potent and selective inhibitor of PI3-kinase γ (PI3Kγ), IC50 = 8 nM displaying 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα.1 Suppresses joint inflammation in two distinct mouse models.1 Ameliorates surgical brain injury2, colitis3, intimal hyperplasia-induced inflammatory processes4 and renal injury/fibrosis5 in rodent models. Orally active.
References/Citations:
1) Camps et al. (2005), Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis; Nature Med., 11 936
2) Huang et al. (2015), Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury; J. Neurosci., 35 10390
3) Peng et al. (2010), Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice; J. Pharmacol. Exp. Ther., 332 46
4) Smimova et al. (2014), Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response; J. Exp. Med., 211 1779
5) Yu et al. (2018), A blockade of PI3Kγ signaling effectively mitigates angiotensin II-induced renal injury and fibrosis in a mouse model; Sci. Rep., 8 10988
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AS-605240 (648450-29-7) is a potent and selective inhibitor of PI3-kinase γ (PI3Kγ), IC50 = 8 nM displaying 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα.1 Suppresses joint inflammation in two distinct mouse models.1 Ameliorates surgical brain injury2, colitis3, intimal hyperplasia-induced inflammatory processes4 and renal injury/fibrosis5 in rodent models. Orally active.
References/Citations:
1) Camps et al. (2005), Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis; Nature Med., 11 936
2) Huang et al. (2015), Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury; J. Neurosci., 35 10390
3) Peng et al. (2010), Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice; J. Pharmacol. Exp. Ther., 332 46
4) Smimova et al. (2014), Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response; J. Exp. Med., 211 1779
5) Yu et al. (2018), A blockade of PI3Kγ signaling effectively mitigates angiotensin II-induced renal injury and fibrosis in a mouse model; Sci. Rep., 8 10988
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