AS-8351 | KDM5B histone demethylase inhibitor

CAS:
796-42-9
Catalog Number:
10-1597
Activity:
KDM5B histone demethylase inhibitor
Chemical Names:
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
Molecular Weight:
291.30
Molecular Formula:
C17H13N3O2
Solubility:
Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$50.00
25 mg$200.00

AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1

References/Citations:

1) Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science, 352 1216

CAS:
796-42-9
Catalog Number:
10-1597
Activity:
KDM5B histone demethylase inhibitor
Chemical Names:
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
Molecular Weight:
291.30
Molecular Formula:
C17H13N3O2
Solubility:
Soluble in DMSO (45 mg/ml); ethanol (10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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