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AS-8351 | KDM5B histone demethylase inhibitor

AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1

References/Citations

1) Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science, 352 1216

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Focus Biomolecules cell signaling supplier, chemical structure AS-8351 | KDM5B histone demethylase inhibitor | CAS 796-42-9

Catalog#  10-1597-0005

$50.00
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CAS:
796-42-9
Catalog Number:
10-1597
Activity:
KDM5B histone demethylase inhibitor
Chemical Name:
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
Alternate Names:
NSC-51355
Molecular Weight:
Molecular Formula:
C17H13N3O2
Solubility:
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml), or in Ethanol (up to 10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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