Ascochlorin | Mitochondrial cytochrome bc1 complex inhibitor

Ascochlorin (26166-39-2) is a novel isoprenoid phenol isolated from Acremonium egyptiacum and other species.¹  It is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory chain complex III) acting at both active sites.²  It induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages³ resulting in anti-inflammatory effects⁴. Demonstrates substantial antineoplastic effects in a variety of tumor cell lines and mouse models.⁵

References/Citations:

1. Tamura et al. (1968), Ascochlorin, a new antibiotic, found by the paper-disc agar diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics.I); J. Antibiot. (Tokyo) 21 539
2. Berry et al. (2010), Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex; Biochim. Biophys. Acta 1797 360
3. Park et al. (2019), Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages; J. Ethnopharmacol. 239 111898
4. Lee et al. (2016), Anti-inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-kB, ERK1/2, and p38 Signaling Pathway; J. Cell Biochem. 108 199
5. Min-Wen et al. (2017), Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy; Adv. Protein Chem. Struct. Biol. 108 199