Ascochlorin | Mitochondrial cytochrome bc1 complex inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 100 ug | $65.00 | ||
| 500 ug | $210.00 |
Ascochlorin (26166-39-2) is a novel isoprenoid phenol isolated from Acremonium egyptiacum and other species.1 It is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory chain complex III) acting at both active sites.2 It induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages3 resulting in anti-inflammatory effects4. Demonstrates substantial antineoplastic effects in a variety of tumor cell lines and mouse models.5
References/Citations:
- Tamura et al. (1968), Ascochlorin, a new antibiotic, found by the paper-disc agar diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics.I); J. Antibiot. (Tokyo) 21 539
- Berry et al. (2010), Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex; Biochim. Biophys. Acta 1797 360
- Park et al. (2019), Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages; J. Ethnopharmacol. 239 111898
- Lee et al. (2016), Anti-inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-kB, ERK1/2, and p38 Signaling Pathway; J. Cell Biochem. 108 199
- Min-Wen et al. (2017), Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy; Adv. Protein Chem. Struct. Biol. 108 199
C23H29O4
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ascochlorin (26166-39-2) is a novel isoprenoid phenol isolated from Acremonium egyptiacum and other species.1 It is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory chain complex III) acting at both active sites.2 It induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages3 resulting in anti-inflammatory effects4. Demonstrates substantial antineoplastic effects in a variety of tumor cell lines and mouse models.5
References/Citations:
- Tamura et al. (1968), Ascochlorin, a new antibiotic, found by the paper-disc agar diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics.I); J. Antibiot. (Tokyo) 21 539
- Berry et al. (2010), Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex; Biochim. Biophys. Acta 1797 360
- Park et al. (2019), Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages; J. Ethnopharmacol. 239 111898
- Lee et al. (2016), Anti-inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-kB, ERK1/2, and p38 Signaling Pathway; J. Cell Biochem. 108 199
- Min-Wen et al. (2017), Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy; Adv. Protein Chem. Struct. Biol. 108 199
Related products
-
HPI-1 | Hedgehog pathway inhibitor
From $75.00CAS:599150-20-6 (anhydrous)Catalog Number:10-4522Activity:Hedgehog pathway inhibitorChemical Name:2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylateMolecular Weight:463.52 (anhydrous)Molecular Formula:C27H29NO6 xH20Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLC
NMR (conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
PNU 74654 | Wnt pathway blocker
From $55.00CAS:113906-27-7Catalog Number:10-4519Activity:Wnt pathway blockerChemical Name:2-Phenoxybenzoic acid [(5-methyl-2-furanyl)methylene]hydrazideMolecular Weight:320.35Molecular Formula:C19H16N2O3Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Off-white solidPurity:>98% by TLC
NMR (conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
Ibrutinib | BTK inhibitor
From $40.00CAS:936563-96-1Catalog Number:10-4757Alternate Name:PCI-32765Activity:BTK inhibitor/Cancer immunotherapy enhancerChemical Name:1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-oneMolecular Weight:440.51Molecular Formula:C25H24N6O2Solubility:Soluble in DMSO ( up to at least 25 mg/ml)Physical Properties:White or off-white solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
