Ascochlorin | Mitochondrial cytochrome bc1 complex inhibitor
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| Size: | Price | Quantity | |
|---|---|---|---|
| 100 ug | $65.00 | ||
| 500 ug | $210.00 |
Ascochlorin (26166-39-2) is a novel isoprenoid phenol isolated from Acremonium egyptiacum and other species.1 It is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory chain complex III) acting at both active sites.2 It induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages3 resulting in anti-inflammatory effects4. Demonstrates substantial antineoplastic effects in a variety of tumor cell lines and mouse models.5
References/Citations:
- Tamura et al. (1968), Ascochlorin, a new antibiotic, found by the paper-disc agar diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics.I); J. Antibiot. (Tokyo) 21 539
- Berry et al. (2010), Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex; Biochim. Biophys. Acta 1797 360
- Park et al. (2019), Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages; J. Ethnopharmacol. 239 111898
- Lee et al. (2016), Anti-inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-kB, ERK1/2, and p38 Signaling Pathway; J. Cell Biochem. 108 199
- Min-Wen et al. (2017), Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy; Adv. Protein Chem. Struct. Biol. 108 199
C23H29O4
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Ascochlorin (26166-39-2) is a novel isoprenoid phenol isolated from Acremonium egyptiacum and other species.1 It is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory chain complex III) acting at both active sites.2 It induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages3 resulting in anti-inflammatory effects4. Demonstrates substantial antineoplastic effects in a variety of tumor cell lines and mouse models.5
References/Citations:
- Tamura et al. (1968), Ascochlorin, a new antibiotic, found by the paper-disc agar diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics.I); J. Antibiot. (Tokyo) 21 539
- Berry et al. (2010), Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex; Biochim. Biophys. Acta 1797 360
- Park et al. (2019), Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages; J. Ethnopharmacol. 239 111898
- Lee et al. (2016), Anti-inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-kB, ERK1/2, and p38 Signaling Pathway; J. Cell Biochem. 108 199
- Min-Wen et al. (2017), Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy; Adv. Protein Chem. Struct. Biol. 108 199
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