Asunaprevir | HCV NS3 protease inhibitor/CRISPR enhancer
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $295.00 |
Asunaprevir (630420-16-5) is a potent hepatitis C virus NS3 protease inhibitor (IC50 = 0.2 – 3.5 nM).1 Asunaprevir was used as part of a repressible Cas9 system (small molecule-assisted shut off – SMASh) capable of degrading newly synthesized Cas9 protein rapidly to precisely control gene editing.2,3 The Asunapreivr/SMASh system has also been using to target endogenous PD-1 protein for proteasomal degradation.4
References/Citations:
- McPhee et al. (2012), Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir; Antimicrob. Agents Chemother. 56 5387
- Chung et al. (2015), Tunable and reversible drug control of protein production via a self-excising degron; Nat. Chem. Biol. 11 713
- Wu et al. (2020), A Small Molecule-Controlled Cas9 Repressible System; Mol.Ther. Nucleic Acids 19 922
- Naruse et al. (2022), A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice; NAR Cancer 4 zcac019
C35H46ClN5O9S
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Asunaprevir (630420-16-5) is a potent hepatitis C virus NS3 protease inhibitor (IC50 = 0.2 – 3.5 nM).1 Asunaprevir was used as part of a repressible Cas9 system (small molecule-assisted shut off – SMASh) capable of degrading newly synthesized Cas9 protein rapidly to precisely control gene editing.2,3 The Asunapreivr/SMASh system has also been using to target endogenous PD-1 protein for proteasomal degradation.4
References/Citations:
- McPhee et al. (2012), Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir; Antimicrob. Agents Chemother. 56 5387
- Chung et al. (2015), Tunable and reversible drug control of protein production via a self-excising degron; Nat. Chem. Biol. 11 713
- Wu et al. (2020), A Small Molecule-Controlled Cas9 Repressible System; Mol.Ther. Nucleic Acids 19 922
- Naruse et al. (2022), A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice; NAR Cancer 4 zcac019
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