Atazanavir | HIV protease inhibitor
CAS:
198904-31-3
Catalog Number:
10-5630
Activity:
HIV protease inhibitor
Chemical Names:
Methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
Alternate Name:
BMS 232632; CGP 73547; Latazanavir
Molecular Weight:
704.87
Molecular Formula:
C38H52N6O7
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $160.00 |
Atazanavir (198904-31-3) is an azapeptide-based inhibitor of HIV protease (Ki = 2.66 nM).1 Inhibits SARS-CoV-2 main protease (Ki = 703 nM), but not papain-like protease (Ki = 9.87 µM).2 Blocks SARS-CoV-2 replication and IL-6 / TNFα production in vitro.3 Also inhibits the liver enzyme UDP-glucuronyltransferase 1A1 (UGT1A1), IC50 = 160 nM for recombinant UGT1A1.4
References/Citations:
- Robinson et al. (2000), BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents; Antimicrob. Agents Chemother. 44 2093
- Chaves et al. (2021), Atazanavir is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo; Pharmaceuticals (Basel) 15 21
- Fintelman-Rodrigues et al. (2020), Atazanavir, Alone or in Combination with Ritonavir, Inhibits SARS-CoV-2 Replication and Proinflammatory Cytokine Production; Antimicrob. Agents Chemother. 64 e00825
- Mullapudi et al. (2021), UGT1A1 and UGT1A3 activity and inhibition in human liver and intestinal microsomes and a recombinant UGT system under similar assay conditions using selective substrates and inhibitors; Xenobiotica 51 1236
CAS:
198904-31-3
Catalog Number:
10-5630
Activity:
HIV protease inhibitor
Chemical Names:
Methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate
Alternate Name:
BMS 232632; CGP 73547; Latazanavir
Molecular Weight:
704.87
Molecular Formula:
C38H52N6O7
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Atazanavir (198904-31-3) is an azapeptide-based inhibitor of HIV protease (Ki = 2.66 nM).1 Inhibits SARS-CoV-2 main protease (Ki = 703 nM), but not papain-like protease (Ki = 9.87 µM).2 Blocks SARS-CoV-2 replication and IL-6 / TNFα production in vitro.3 Also inhibits the liver enzyme UDP-glucuronyltransferase 1A1 (UGT1A1), IC50 = 160 nM for recombinant UGT1A1.4
References/Citations:
- Robinson et al. (2000), BMS-232632, a highly potent human immunodeficiency virus protease inhibitor that can be used in combination with other available antiretroviral agents; Antimicrob. Agents Chemother. 44 2093
- Chaves et al. (2021), Atazanavir is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo; Pharmaceuticals (Basel) 15 21
- Fintelman-Rodrigues et al. (2020), Atazanavir, Alone or in Combination with Ritonavir, Inhibits SARS-CoV-2 Replication and Proinflammatory Cytokine Production; Antimicrob. Agents Chemother. 64 e00825
- Mullapudi et al. (2021), UGT1A1 and UGT1A3 activity and inhibition in human liver and intestinal microsomes and a recombinant UGT system under similar assay conditions using selective substrates and inhibitors; Xenobiotica 51 1236
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