Auranofin | IKK inhibitor

CAS:
34031-32-8
Catalog Number:
10-2373
Activity:
IKK inhibitor
Alternate Names:
SKF-39162
Chemical Name:
1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate
Molecular Weight:
678.49
Molecular Formula:
C20H34AuO9PS
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 4 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
25 mg$50.00
This product is also available in the following library:

Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions.

References/Citations:

1) Columbo et al. (1990), Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin; Biochem. Pharmacol., 39 285
2) Rigobello et al. (2002), Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative; Br. J. Pharmacol., 136 1162
3) Merck 14 878

CAS:
34031-32-8
Catalog Number:
10-2373
Activity:
IKK inhibitor
Alternate Names:
SKF-39162
Chemical Name:
1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate
Molecular Weight:
678.49
Molecular Formula:
C20H34AuO9PS
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 4 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!