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Product Details

Auranofin | IKK inhibitor

Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions.

References/Citations
1) Columbo et al. (1990), Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin; Biochem. Pharmacol., 39 285
2) Rigobello et al. (2002), Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative; Br.J. Pharmacol., 136 1162
3) Merck 14 878

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Catalog#  10-2373

$50.00
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CAS:
34031-32-8
Catalog Number:
10-2373
Activity:
IKK inhibitor
Alternate Names:
SKF-39162
Chemical Name:
1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate
Molecular Weight:
678.49
Molecular Formula:
C20H34AuO9PS
Solubility:
Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 4 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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