Vinblastine sulfate | Microtubule depolymerizer
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $48.00 | ||
| 25 mg | $192.00 |
Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant tubulin polymerization.1 Vinblastine sulfate induces apoptosis in a variety of cell lines.2 Inhibits autophagosome maturation.3 Inhibits palmitoylation of tubulin.4
References/Citations:
1) Hamel et al. (1996), Antimitotic natural products and their interactions with tubulin; Med. Res. Rev., 16 207
2) Tsukidate et al. (1993), Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes; Am. J. Pathol., 143 918
3) Satori et al. (2013), Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection; Anal. Chem., 85 11391
4) Caron and Herwood (2007), Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes; Chemotherapy, 53 51
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Vinblastine sulfate (143-67-9) is a semisynthetic alkaloidal anticancer agent. Induces cell cycle arrest at G2/M phase by inhibiting mitotic spindle formation.1 Inhibits normal microtubule assembly and induces aberrant tubulin polymerization.1 Vinblastine sulfate induces apoptosis in a variety of cell lines.2 Inhibits autophagosome maturation.3 Inhibits palmitoylation of tubulin.4
References/Citations:
1) Hamel et al. (1996), Antimitotic natural products and their interactions with tubulin; Med. Res. Rev., 16 207
2) Tsukidate et al. (1993), Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes; Am. J. Pathol., 143 918
3) Satori et al. (2013), Describing autophagy via analysis of individual organelles by capillary electrophoresis with laser induced fluorescence detection; Anal. Chem., 85 11391
4) Caron and Herwood (2007), Vinblastine, a chemotherapeutic drug, inhibits palmitoylation of tubulin in human leukemic lymphocytes; Chemotherapy, 53 51
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