AZD5904 | Myeloperoxidase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $280.00 |
AZD5904 (618913-30-7) is a mechanism-based inactivator of myeloperoxidase (IC50 = 200 nM), reacting with hydrogen peroxide in neutrophils to inactivate the enzyme.1 This prevents production of hypochlorous acid and concomitant oxidative stress. Importantly, neutrophil bactericidal activity was slowed but not stopped. AZD5904 did not inactivate thyroid peroxidase or lactoperoxidase. AZD5904 prevented the onset and reversed established high-fat diet induced microvascular insulin resistance.2 It also alleviated the relaxation defect in hypertrophic induced pluripotent cardiomyocytes via restoration of MYBPC3 phosphorylation, suggesting potential therapeutic value in treating hypertrophic cardiomyopathy.3
References/Citations:
- Tiden et al. (2011), 2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation; J. Biol. Chem. 286 37578
- Chai et al. (2019), Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance; Am. J. Physiol. Endocrinol. Metab., 317 E1063
- Ramachandra et al. (2022), Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes; Cardiovasc. Res. 118 517
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AZD5904 (618913-30-7) is a mechanism-based inactivator of myeloperoxidase (IC50 = 200 nM), reacting with hydrogen peroxide in neutrophils to inactivate the enzyme.1 This prevents production of hypochlorous acid and concomitant oxidative stress. Importantly, neutrophil bactericidal activity was slowed but not stopped. AZD5904 did not inactivate thyroid peroxidase or lactoperoxidase. AZD5904 prevented the onset and reversed established high-fat diet induced microvascular insulin resistance.2 It also alleviated the relaxation defect in hypertrophic induced pluripotent cardiomyocytes via restoration of MYBPC3 phosphorylation, suggesting potential therapeutic value in treating hypertrophic cardiomyopathy.3
References/Citations:
- Tiden et al. (2011), 2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation; J. Biol. Chem. 286 37578
- Chai et al. (2019), Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance; Am. J. Physiol. Endocrinol. Metab., 317 E1063
- Ramachandra et al. (2022), Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes; Cardiovasc. Res. 118 517
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