AZD7648 | DNA-PK inhibitor/CRISPR enhancer
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $240.00 |
AZD7648 (2230820-11-6) is a very potent and selective (against 397 kinases) DNA-PK inhibitor (pIC50 = 9.2; cellular pIC50 = 7.0).1 It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models.2 AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone3,4,5 or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail)5.
References/Citations:
- Goldberg et al. (2020), The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridine-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor; J. Med. Chem. 63 3461
- Fok et al. (2019), AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and Olaparib activity; Nat. Commun. 10 5065
- Cloarec-Ung et al. (2024), Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells; Elife 12 RP91288
- Selvaraj et al. (2024), High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition; Nat. Biotech. 42 731
- Wimberger et al. (2023), Simultaneous inhibition of DNA-PK and PolΘ improves integration efficiency and precision of genome editing; Nat. Commun. 14 4761
C18H20N8O2
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AZD7648 (2230820-11-6) is a very potent and selective (against 397 kinases) DNA-PK inhibitor (pIC50 = 9.2; cellular pIC50 = 7.0).1 It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models.2 AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone3,4,5 or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail)5.
References/Citations:
- Goldberg et al. (2020), The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridine-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor; J. Med. Chem. 63 3461
- Fok et al. (2019), AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and Olaparib activity; Nat. Commun. 10 5065
- Cloarec-Ung et al. (2024), Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells; Elife 12 RP91288
- Selvaraj et al. (2024), High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition; Nat. Biotech. 42 731
- Wimberger et al. (2023), Simultaneous inhibition of DNA-PK and PolΘ improves integration efficiency and precision of genome editing; Nat. Commun. 14 4761
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