Azoramide | UPR modulator

CAS:
932986-18-0
Catalog Number:
10-4629
Activity:
UPR modulator
Chemical Name:
N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
Molecular Weight:
308.83
Molecular Formula:
C15H17ClN2OS
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in ethanol (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$50.00
50 mg$175.00

Azoramide (932986-18-0) is a modulator of the unfolded protein response (UPR).1  It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It displayed potent anti-diabetic activity in two mouse models by improving insulin sensitivity and pancreatic b cell function. Azoramide increased SERCA expression leading to enhanced calcium retention in the ER indicating calcium homeostasis as a possible mechanism for its anti-diabetic activity.

References/Citations:

1) Fu (2015), Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity; Sci. Transl. Med., 7 292ra98

CAS:
932986-18-0
Catalog Number:
10-4629
Activity:
UPR modulator
Chemical Name:
N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide
Molecular Weight:
308.83
Molecular Formula:
C15H17ClN2OS
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in ethanol (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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