b-AP15 | DUB inhibitor

CAS:
1009817-63-3
Catalog Number:
10-1340
Activity:
DUB inhibitor
Alternate Names:
NSC-687852
Chemical Name:
3,5-bis[(4-Nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one
Molecular Weight:
419.4
Molecular Formula:
C22H17N3O6
Solubility:
Soluble in DMSO (up to 35 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
>98% by HPLC
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$55.00
25 mg$215.00

b-AP15 (1009817-63-3) abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.

References/Citations:

1) D’Arcy et al. (2011), Inhibition of proteasome deubiquitinating activity as a new cancer therapy; Nature Medicine, 17 1636

CAS:
1009817-63-3
Catalog Number:
10-1340
Activity:
DUB inhibitor
Alternate Names:
NSC-687852
Chemical Name:
3,5-bis[(4-Nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one
Molecular Weight:
419.4
Molecular Formula:
C22H17N3O6
Solubility:
Soluble in DMSO (up to 35 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
>98% by HPLC
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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