B02 | RAD51 inhibitor

CAS:
 1290541-46-6
Catalog Number:
 10-3425
B02 chemical structure

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RAD51 is a key protein involved in homologous recombination that plays a critical role in the repair of DNA double-strand breaks (DSB) and interstrand cross-links (ICL).1 B02 (1290541-46-6) was identified in a high-throughput screen using a DNA strand exchange assay and was found to specifically inhibit human RAD51 (IC50=27.4 µM) but not its E. coli homolog (RecA)1. It sensitizes multiple myeloma cells to doxorubicin2 and  potentiates breast cancer cell killing by therapeutic agents in mouse models3.  B02 induces a heat-shock protein mediated cellular response that positively regulates the conversion of rcDNA to cccDNA via the authentic intracellular amplification pathway in human hepatoma cells.4

References/Citations:

  1. Huang et al. (2011), Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening; ACS Chem. Biol., 6 628
  2. Alagpulinsa et al. (2014), A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin; Front. fOncol., 4 289
  3. Huang and Mazin (2014), A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts; PLoS One, 9 e100993
  4. Tang et al. (2023), Heat Shock Protein Family A Member 1 Promotes Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA; J. Virol., 97 e0126122
1290541-46-6, B-02, B02, B02 supplier, RAD51 inhibitor
CAS:
1290541-46-6
Catalog Number:
10-3425
Activity:
RAD51 inhibitor
Chemical Names:
3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
Molecular Weight:
339.40
Molecular Formula:

C22H17N3O

Solubility:
Soluble in DMSO (35 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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RAD51 is a key protein involved in homologous recombination that plays a critical role in the repair of DNA double-strand breaks (DSB) and interstrand cross-links (ICL).1 B02 (1290541-46-6) was identified in a high-throughput screen using a DNA strand exchange assay and was found to specifically inhibit human RAD51 (IC50=27.4 µM) but not its E. coli homolog (RecA)1. It sensitizes multiple myeloma cells to doxorubicin2 and  potentiates breast cancer cell killing by therapeutic agents in mouse models3.  B02 induces a heat-shock protein mediated cellular response that positively regulates the conversion of rcDNA to cccDNA via the authentic intracellular amplification pathway in human hepatoma cells.4

References/Citations:

  1. Huang et al. (2011), Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening; ACS Chem. Biol., 6 628
  2. Alagpulinsa et al. (2014), A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin; Front. fOncol., 4 289
  3. Huang and Mazin (2014), A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts; PLoS One, 9 e100993
  4. Tang et al. (2023), Heat Shock Protein Family A Member 1 Promotes Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA; J. Virol., 97 e0126122

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