Bafilomycin A1 | Vacuolar H+ ATPase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 ug | $40.00 | ||
| 1 mg | $172.00 |
Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via disruption of fusion between autophagosomes and lysosomes.3
References/Citations:
1) Werner et al. (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot., 37 110
2) Drose and Altendorf (1997) Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase; J. Exp. Biol., 200 1
3) Yamamoto et al. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells; Cell Struct. Func., 23 33
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via disruption of fusion between autophagosomes and lysosomes.3
References/Citations:
1) Werner et al. (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot., 37 110
2) Drose and Altendorf (1997) Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase; J. Exp. Biol., 200 1
3) Yamamoto et al. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells; Cell Struct. Func., 23 33
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
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1-855-FOCUS21
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