Size: | Price | Quantity | |
---|---|---|---|
5 mg | $80.00 | ||
25 mg | $245.00 |
BAY-876 (1799753-84-6) is a potent inhibitor (IC50 = 2 nM) of the facilitative glucose transporter GLUT1, an enzyme frequently overexpressed in many cancers.1 It shows greater than 100-fold selectivity over GLUT2-4. BAY-876 displayed potent antitumor activity in ovarian cancer xenograft models2 and in triple negative breast cancer cells displaying high glycolytic and low oxidative phosphorylation rates3. It reduced CD4+ T cell proliferation and IFN-γ secretion via GLUT1 inhibition suggesting utility against auto-inflammatory diseases.4 BAY-876 induces disulfidptosis in SLCA11high cancer cells.5
References/Citations:
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BAY-876 (1799753-84-6) is a potent inhibitor (IC50 = 2 nM) of the facilitative glucose transporter GLUT1, an enzyme frequently overexpressed in many cancers.1 It shows greater than 100-fold selectivity over GLUT2-4. BAY-876 displayed potent antitumor activity in ovarian cancer xenograft models2 and in triple negative breast cancer cells displaying high glycolytic and low oxidative phosphorylation rates3. It reduced CD4+ T cell proliferation and IFN-γ secretion via GLUT1 inhibition suggesting utility against auto-inflammatory diseases.4 BAY-876 induces disulfidptosis in SLCA11high cancer cells.5
References/Citations:
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