BD1047 dihydrobromide | Selective sigma-1 antagonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $195.00 |
BD1047 (138356-21-5) is a potent and selective sigma-1 antagonist (IC50’s: σ1 = 0.93nM, σ2 = 47nM) .1 Pretreatment of mice with BD1047 reduced convulsions, lethality, and locomotor activity induced by cocaine.2 BD1047 attenuated high fat diet-induced peripheral neuropathy in mice.3 BD1047 displayed antinociceptive effects in several rodent pain models.4-6 It also inhibits the β-adrenoreceptor (IC50 = 145 nM).1
References/Citations:
1) Matsumoto et al. (1995), Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism; Eur. J. Pharmacol. 280 301
2) McCracken et al. (1999), Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity; Eur. J. Pharmacol. 370 225
3) Song et al. (2017), Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy; Biol. Chem. 398 1141
4) Jeong et al. (2005), The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats; Brain Res. Bull. 119(Pt.A) 93
5) Roh and Yoon (2014), Sigma-1 receptor antagonist BD1047 reduces nociceptive response and phosphorylation of p38 MAPK in mice orofacial formalin model; Biol. Pharm. Bull. 37 145
6) Zhu et al. (2015), Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation; Mediators Inflamm. 2015 265056
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
BD1047 (138356-21-5) is a potent and selective sigma-1 antagonist (IC50’s: σ1 = 0.93nM, σ2 = 47nM) .1 Pretreatment of mice with BD1047 reduced convulsions, lethality, and locomotor activity induced by cocaine.2 BD1047 attenuated high fat diet-induced peripheral neuropathy in mice.3 BD1047 displayed antinociceptive effects in several rodent pain models.4-6 It also inhibits the β-adrenoreceptor (IC50 = 145 nM).1
References/Citations:
1) Matsumoto et al. (1995), Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism; Eur. J. Pharmacol. 280 301
2) McCracken et al. (1999), Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity; Eur. J. Pharmacol. 370 225
3) Song et al. (2017), Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy; Biol. Chem. 398 1141
4) Jeong et al. (2005), The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats; Brain Res. Bull. 119(Pt.A) 93
5) Roh and Yoon (2014), Sigma-1 receptor antagonist BD1047 reduces nociceptive response and phosphorylation of p38 MAPK in mice orofacial formalin model; Biol. Pharm. Bull. 37 145
6) Zhu et al. (2015), Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation; Mediators Inflamm. 2015 265056
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