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BD1047 dihydrobromide | Selective sigma-2 antagonist

BD1047 (138356-21-5) is a potent and selective sigma-1 antagonist (IC50’s:  σ1 = 0.93nM, σ2 = 47nM). .1 Pretreatment of mice with BD1047 reduced convulsions, lethality, and locomotor activity induced by cocaine.2 BD1047 attenuated high fat diet-induced peripheral neuropathy in mice.3 BD1047 displayed antinociceptive effects in several rodent pain models.4-6 It also inhibits the β-adrenoreceptor (IC50 = 145 nM).1


1) Matsumoto et al. (1995), Characterisation of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism; Eur. J. Pharmacol. 280 301
2) McCracken et al. (1999), Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity; Eur. J. Pharmacol. 370 225
3) Song et al. (2017), Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy; Biol. Chem. 398 1141
4) Jeong et al. (2005), The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats; Brain Res. Bull. 119(Pt.A) 93
5) Roh and Yoon (2014), Sigma-1 receptor antagonist BD1047 reduces nociceptive response and phosphorylation of p38 MAPK in mice orofacial formalin model; Biol. Pharm. Bull. 37 145
6) Zhu et al. (2015), Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation; Mediators Inflamm. 2015 265056

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Catalog#  10-4210-0005

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Catalog Number:
Selective sigma-1 antagonist
Chemical Name:
N-[2-(3,4Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide
Molecular Weight:
Molecular Formula:
C13H20Cl2N2 • 2HBr
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
Physical Properties:
Off-white solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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