BD1063 dihydrochloride | Selective sigma-1 antagonist
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $195.00 |
BD1063 (206996-13-6) is potent and selective sigma-1 antagonist (IC50’s: σ1 = 9nM, σ2 = 449nM).1 BD1063 abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner.2 BD1063 potentiated µ-opioid antinociception in mice in a sigma-dependent manner.3 BD1063 has been used in animal models to successfully treat compulsive eating4 and excessive ethanol drinking5.
References/Citations:
1) Matsumoto et al. (1995), Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest &sigma receptor antagonism; Eur. J. Pharmacol. 280 301
2) Tejada et al. (2017), Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice; Proc. Natl. Acad. Sci. USA 114 8396
3) Sanchez-Fernandez et al. (2014), Modulation of peripheral µ-opioid analgesia by σ1 receptors; J. Pharmacol. Exp. Ther. 348 32
4) Cottone et al. (2012), Antagonism of sigma-1 receptors blocks compulsive-like eating; Neuropsychopharmaology 37 2593
5) Sabino et al. (2009), The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking; Neuropsychopharmaology 34 1482
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
BD1063 (206996-13-6) is potent and selective sigma-1 antagonist (IC50’s: σ1 = 9nM, σ2 = 449nM).1 BD1063 abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner.2 BD1063 potentiated µ-opioid antinociception in mice in a sigma-dependent manner.3 BD1063 has been used in animal models to successfully treat compulsive eating4 and excessive ethanol drinking5.
References/Citations:
1) Matsumoto et al. (1995), Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest &sigma receptor antagonism; Eur. J. Pharmacol. 280 301
2) Tejada et al. (2017), Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice; Proc. Natl. Acad. Sci. USA 114 8396
3) Sanchez-Fernandez et al. (2014), Modulation of peripheral µ-opioid analgesia by σ1 receptors; J. Pharmacol. Exp. Ther. 348 32
4) Cottone et al. (2012), Antagonism of sigma-1 receptors blocks compulsive-like eating; Neuropsychopharmaology 37 2593
5) Sabino et al. (2009), The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking; Neuropsychopharmaology 34 1482
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