Bepridil | Calcium channel blocker\Active against SARS-CoV2
CAS:
74764-40-2
Catalog Number:
10-4958
Activity:
Calcium channel blocker/anti-SARS-CoV2
Chemical Name:
N-Benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline hydrochloride
Molecular Weight:
403.00
Molecular Formula:
C24H34N2O·HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $40.00 | ||
| 25 mg | $125.00 |
Bepridil (74764-40-2) is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activity against SARS-CoV-2 in vitro.2 Bepridil was also able to provide protection from Ebola virus3 and other filoviruses in a mouse model4. Blocker of the Na+/Ca2+ exchanger (NCX).5
References:
- Hollingshead et al. (1992), A review of its pharmacological properties and therapeutic use in stable angina pectoris; Drugs, 44 835
- Vatansever et al. (2021), Bepridil is potent against SARS-CoV-2 in vitro; Proc. Natl. Acad. Sci USA, 118 e2012201118
- Johansen et al. (2015), A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity; Sci. Transl. Med., 7 290ra89
- DeWald et al. (2018), The calcium channel blocker bepridil demonstrates efficacy in the murine model of marburg virus disease; J. Infect. Dis., 218(suppl 5) S588
- Wantanabe and Kimura (2001), Blocking effect of bepridil on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes; Jpn. J. Pharmacol. 85 370
CAS:
74764-40-2
Catalog Number:
10-4958
Activity:
Calcium channel blocker/anti-SARS-CoV2
Chemical Name:
N-Benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline hydrochloride
Molecular Weight:
403.00
Molecular Formula:
C24H34N2O·HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Bepridil (74764-40-2) is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activity against SARS-CoV-2 in vitro.2 Bepridil was also able to provide protection from Ebola virus3 and other filoviruses in a mouse model4. Blocker of the Na+/Ca2+ exchanger (NCX).5
References:
- Hollingshead et al. (1992), A review of its pharmacological properties and therapeutic use in stable angina pectoris; Drugs, 44 835
- Vatansever et al. (2021), Bepridil is potent against SARS-CoV-2 in vitro; Proc. Natl. Acad. Sci USA, 118 e2012201118
- Johansen et al. (2015), A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity; Sci. Transl. Med., 7 290ra89
- DeWald et al. (2018), The calcium channel blocker bepridil demonstrates efficacy in the murine model of marburg virus disease; J. Infect. Dis., 218(suppl 5) S588
- Wantanabe and Kimura (2001), Blocking effect of bepridil on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes; Jpn. J. Pharmacol. 85 370
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