BG45 | HDAC3 selective inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $60.00 | ||
| 25mg | $240.00 |
BG45 (926259-99-6) is a potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibits tumor growth in a mouse xenograft model of human multiple myeloma.1 Downregulates expression of DNA methyltransferase 1.2 Increases expression of synaptic proteins in exogenous Aβ-treated cells and mice.3 Rescues synaptic damage and neuron loss in APP-transfected cells (15 mM) and APP/PS1 mice (30 mg/kg).4
References/Citations:
- Minami et al. (2014), Histone deacetylase 3 as a novel therapeutic target in multiple myeloma; Leukemia, 28 680
- Harada et al. (2017), HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications; Leukemia, 31 2670
- Han et al. (2021), Class I HDAC Inhibitor Improves Synaptic Proteins and Repairs Cytoskeleton Through Regulating Synapse-Related Genes In vitro and In vivo; Front. Aging Neurosci., 12 619866
- Han et al. (2022), A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway; Molecules, 27 4160
C11H10N4O
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
BG45 (926259-99-6) is a potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibits tumor growth in a mouse xenograft model of human multiple myeloma.1 Downregulates expression of DNA methyltransferase 1.2 Increases expression of synaptic proteins in exogenous Aβ-treated cells and mice.3 Rescues synaptic damage and neuron loss in APP-transfected cells (15 mM) and APP/PS1 mice (30 mg/kg).4
References/Citations:
- Minami et al. (2014), Histone deacetylase 3 as a novel therapeutic target in multiple myeloma; Leukemia, 28 680
- Harada et al. (2017), HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications; Leukemia, 31 2670
- Han et al. (2021), Class I HDAC Inhibitor Improves Synaptic Proteins and Repairs Cytoskeleton Through Regulating Synapse-Related Genes In vitro and In vivo; Front. Aging Neurosci., 12 619866
- Han et al. (2022), A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway; Molecules, 27 4160
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