BI 9564 | BRD9 bromodomain inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $60.00 | ||
| 25mg | $195.00 |
BI 9564 (1883429-22-8) is a potent, selective, and cell permeable inhibitor of the BRD9 bromodomain, a subunit of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex (IC50 = 75 nM).1 It displayed antitumor activity in an acute myeloid leukemia xenograft model. BI-9564 displayed cytotoxic and anti-proliferative effects in 5 rhabdoid tumor cell lines.2
References/Citations:
- Martin et al. (2016), Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor; J. Med. Chem., 59 4462
- Krämer et al. (2017), BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors; Int. J. Mol. Sci., 18 1537
C20H23N3O3
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
BI 9564 (1883429-22-8) is a potent, selective, and cell permeable inhibitor of the BRD9 bromodomain, a subunit of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex (IC50 = 75 nM).1 It displayed antitumor activity in an acute myeloid leukemia xenograft model. BI-9564 displayed cytotoxic and anti-proliferative effects in 5 rhabdoid tumor cell lines.2
References/Citations:
- Martin et al. (2016), Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor; J. Med. Chem., 59 4462
- Krämer et al. (2017), BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors; Int. J. Mol. Sci., 18 1537
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