Acetyl-CoA (75520-41-1) is an essential cofactor for cellular metabolism, being an ‘activated acetate’ that shuttles its moieties back and forth during anabolic, catabolic, and metabolic processes involving fundamental molecules: fatty acids, amino acids, glucose, and ATP.1 In the laboratory, it can be used as a substrate in chloramphenicol acetyltransferase (CAT) transcription reporter assays2 or in histone acetyltransferase (HAT) assays in epigenetics research3.
References/Citations:
- Wolfe (2005), The acetate switch; Mol. Biol. Rev. 69 12
- Gorman et al. (1982), Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells; Mol. Cell Biol. 2 1044
- Kim et al. (2000), A continuous, nonradioactive assay for histone acetyltransferases; Anal. Biochem. 280 308
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