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Palmitoylethanolamide | GPR-55 agonist

Palmitoylethanolamide (544-31-0) is an endogenous cannabinoid. Weak ligand for CB1 (Ki= 23.8 μM) and CB2 (Ki = 13.9 μM) receptors. Inhibits fatty acid amide hydrolase (FAAH) ((IC50 = 5.1 μM). Modulates mast cell activation. Palmitoylethanolamide displays immunosuppressant, anti-inflammatory and anti-nociceptive activity.

References/Citations
1) De Filippis et al. (2011), Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats; Mol. Pain, 7 3
2) Re et al. (2007), Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in campanion animals; Vet J., 173 21
3) Lambert et al. (2002), The palmitoylethanolamide family: a new class of anti-inflammatory agents?; Curr. Med. Chem., 9 663

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Focus Biomolecules cell signaling reagent supplier, structure of Palmitoylethanolamine | GPR-55 agonist | CAS 544-31-0

Catalog#  10-1297

$60.00
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CAS:
544-31-0
Catalog Number:
10-1297
Activity:
GPR-55 agonist
Alternate Names:
PEA
Chemical Name:
N-(2-Hydroxyethyl)palmitamide
Molecular Weight:
299.49
Molecular Formula:
C18H37NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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