G proteins

G proteins are fundamental signaling components of the cell. G proteins are GTPases, functioning as guanine nucleotide-binding and -hydrolyzing proteins. In the inactive state they are bound to GDP; when they bind GTP (in some cases facilitated by GPCRs), they become active, stimulating and amplifying myriad signaling pathways that ultimately regulate cell growth, differentiation, and migration.

ADP-ribosylation

  • Veliparib 2HCl | PARP 1/2 inhibitor
    CAS:
    912445-05-7
    Catalog Number:
    10-2419
    Activity:
    PARP 1/2 inhibitor
    Chemical Names:
    2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide dihydrochloride
    Alternate Name:
    ABT-888
    Molecular Weight:
    317.22
    Molecular Formula:
    C13H16N4O·2HCl
    Solubility:
    Soluble in DMSO (30 mg/ml); water (40 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • UPF-1069 | PARP-2 inhibitor
    CAS:
    1048371-03-4
    Catalog Number:
    10-3779
    Activity:
    PPAR-2 inhibitor
    Chemical Name:
    5-(2-Oxo-3-phenylethoxy)-1(2H)-isoquinolinone
    Molecular Weight:
    279.29
    Molecular Formula:
    C17H13NO3
    Solubility:
    Soluble in DMSO (up to 40 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Rucaparib phosphate | PARP1 inhibitor
    CAS:
    459868-92-9
    Catalog Number:
    10-3321
    Activity:
    PARP1 inhibitor
    Chemical Name:
    8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
    Alternate Name:
    AG-14699; PF01367338
    Molecular Weight:
    421.36
    Molecular Formula:
    C19H18FN3O • H3PO4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Olaparib | PARP1 inhibitor
    CAS:
    763113-22-0
    Catalog Number:
    10-2154
    Activity:
    PARP1 inhibitor
    Chemical Name:
    4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one
    Alternate Names:
    AZD-2281; KU-59436
    Molecular Weight:
    434.47
    Molecular Formula:
    C24H23FN4O3
    Solubility:
    Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • PJ-34 HCl | PARP1/2 inhibitor
    CAS:
    344458-15-7
    Catalog Number:
    10-2395
    Activity:
    PARP1,2 inhibitor
    Chemical Name:
    N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride
    Molecular Weight:
    331.81
    Molecular Formula:
    C17H17N3O2
    Solubility:
    Soluble in DMSO (up to 30 mg/ml) or in Water (up to 20 mg/ml).
    Physical Properties:
    Yellow solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT (des.)
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All ADP-ribosylation Products

Inhibitors

  • CCG-4986 | RGS4 inhibitor
    CAS:
    7134-19-2
    Catalog Number:
    10-1431
    Activity:
    RGS4 inhibitor
    Chemical Names:
    Methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate
    Molecular Weight:
    374.81
    Molecular Formula:
    C13H11ClN2O5S2
    Solubility:
    Soluble in DMSO (60 mg/ml); Ethanol (5 mg/ml with warming)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • YM-254890 | Gαq inhibitor
    CAS:
    568580-02-9
    Catalog Number:
    10-1590
    Activity:
    Gαq inhibitor
    Source:
    Isolated from Chromobacterium sp.
    Molecular Weight:
    960.1
    Molecular Formula:
    C46H69N7O15
    Solubility:
    Soluble in DMSO (up to 10 mg/ml)
    Physical Properties:
    White or off-white lyophilized solid
    Purity:
    95% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Inhibitors Products

Small G Proteins

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