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Bithionol | Glutamate dehydrogenase inhibitor

CAS:
97-18-7
Catalog Number:
10-4567
Activity:
Glutamate dehydrogenase inhibitor
Chemical Name:
Bis(2-hydroxy-3,5-dichlorophenyl)sulfide
Molecular Weight:
356.05
Molecular Formula:
C12H6Cl4O2S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Bithionol (97-18-7) is an antihelmintic drug with bacteriostatic and fungicidal properties. Bithionol has also been found to be an inhibitor of glutamate dehydrogenase1,2 (IC50 = 4.8 μM bovine GDH1).

References/Citations:

1) Li et al. (2009), Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics; J. Biol. Chem., 284 22988
2) Zocher et al. (2012), Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2; Mol. Biochem. Parasitol., 183 52

Bithionol | Glutamate dehydrogenase inhibitor is also available in the Cellular Metabolism Library.
CAS:
97-18-7
Catalog Number:
10-4567
Activity:
Glutamate dehydrogenase inhibitor
Chemical Name:
Bis(2-hydroxy-3,5-dichlorophenyl)sulfide
Molecular Weight:
356.05
Molecular Formula:
C12H6Cl4O2S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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