Bleomycin sulfate | Induces double strand DNA breaks
95% by HPLC
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $250.00 |
Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal disease models.4,5 Anticancer agent in clinical use.6
References/Citations:
1) Petering et al. (1990), The role of redox-active metals in the mechanism of action of bleomycin; Chem. Biol. Interact., 73 133
2) Huttenhofer et al. (1992), Cleavage of tRNA by Fe(II)-bleomycin; J. Biol. Chem., 267 24471
3) Lee et al. (2017) ASF1a Promotes Non-homologous End Joining Repair by facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks; Mol. Cell 68 61
4) Xie et al. (2016), Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis; Respir. Res., 17 103
5) Inomata et al. (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis; Respir. Res., 15 16
6) Tanaka et al. (2008) Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells; Anticancer Res., 28 2663
95% by HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal disease models.4,5 Anticancer agent in clinical use.6
References/Citations:
1) Petering et al. (1990), The role of redox-active metals in the mechanism of action of bleomycin; Chem. Biol. Interact., 73 133
2) Huttenhofer et al. (1992), Cleavage of tRNA by Fe(II)-bleomycin; J. Biol. Chem., 267 24471
3) Lee et al. (2017) ASF1a Promotes Non-homologous End Joining Repair by facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks; Mol. Cell 68 61
4) Xie et al. (2016), Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis; Respir. Res., 17 103
5) Inomata et al. (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis; Respir. Res., 15 16
6) Tanaka et al. (2008) Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells; Anticancer Res., 28 2663
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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