BML-260 | JSP-1 phosphatase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $200.00 |
BML-260 (101439-76-3) is a potent inhibitor of the dual specificity phosphatase JSP-1 (IC50= 18 µM).1 It promotes the growth of cord blood and mobilizes peripheral blood hematopoietic stem and progenitor cells.2 It increases UCP1 expression in both brown and white adipocytes increasing mitochondrial activity and heat generation, an effect that is JSP-1 independent.3
References/Citations:
- Cutshall et al. (2005), Rhodanine derivatives as inhibitors of JSP-1; Bioorg. Med. Chem. Lett., 15 3374
- Albayrak et al. (2022), BML-260 promotes the growth of cord blood and mobilized peripheral blood hematopoietic stem and progenitor cells with improved reconstitution ability; J. Cell. Biochem., 123 2009
- Feng et al. (2019), Identification of a rhodamine derivative BML-260 as a potent stimulator of UCP1 expression; Theranostics, 9 3501
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
BML-260 (101439-76-3) is a potent inhibitor of the dual specificity phosphatase JSP-1 (IC50= 18 µM).1 It promotes the growth of cord blood and mobilizes peripheral blood hematopoietic stem and progenitor cells.2 It increases UCP1 expression in both brown and white adipocytes increasing mitochondrial activity and heat generation, an effect that is JSP-1 independent.3
References/Citations:
- Cutshall et al. (2005), Rhodanine derivatives as inhibitors of JSP-1; Bioorg. Med. Chem. Lett., 15 3374
- Albayrak et al. (2022), BML-260 promotes the growth of cord blood and mobilized peripheral blood hematopoietic stem and progenitor cells with improved reconstitution ability; J. Cell. Biochem., 123 2009
- Feng et al. (2019), Identification of a rhodamine derivative BML-260 as a potent stimulator of UCP1 expression; Theranostics, 9 3501
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