BML-277 | CHK2 inhibitor

CAS:
516480-79-8
Catalog Number:
10-1024
Activity:
CHK2 inhibitor
Chemical Name:
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Molecular Weight:
363.81
Molecular Formula:
C20H14ClN3O2
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR conforms
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$60.00
25 mg$210.00

BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the selectivity1. Also displays radioprotective activity, preventing apoptosis in human T-cells that were subjected to ionizing radiation (EC50 = 3.0-7.6 μM).

References/Citations:

1) Arienti et al. (2005), Checkpoint kinases inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles; J. Med. Chem., 48 1873
2) Pereg et al. (2006), Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage; Mol. Cell. Biol., 26 6819

CAS:
516480-79-8
Catalog Number:
10-1024
Activity:
CHK2 inhibitor
Chemical Name:
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Molecular Weight:
363.81
Molecular Formula:
C20H14ClN3O2
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR conforms
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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