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Product Details

BMS-309403 | FABP4 inhibitor

BMS-309403 (300657-03-8) is a potent (Ki <2 nM FABP4, Ki = 250 nM FABP3, Ki = 350 nM FABP5) and selective inhibitor of the fatty-acid-binding protein aP2 (FABP4).1,2 It demonstrated marked reductions in atherosclerotic lesions in an Apoe-/- mouse model and improved glucose metabolism, reduced inflammation, and increased insulin sensitivity in a Lepob/obmouse model. BMS-309403 stimulated glucose uptake in myotubes via activation of AMPK.3 It decreased ER stress-associated inflammation in skeletal muscle4 and suppressed inflammation and oxidative stress in mouse and cell models of acute lung injury5.

References/Citations
1) Furuhashi et al. (2007), Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2; Nature 447 959
2) Sulsky et al. (2007), Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP); Bioorg. Med. Chem. Lett., 17 3511
3) Lin et al. (2012), BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase; PLoS One, 7 e44570
4) Bosquet et al. (2018), FABP4 inhibitor BMS3409403 decreases saturated-fatty-acid-induced endoplasmic reticulum stress-associated inflammation in skeletal muscle by reducing p38 MAPK activation; Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1863 604
5) Gongl et al. (2018), FABP4 inhibitors suppress inflammation and oxidative stress in murine and cell models of acute lung injury; Biochem. Biophys. Res. Commun., 496 1115

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Catalog#  10-4762-0005

$60.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
300657-03-8
Catalog Number:
10-4762
Activity:
FABP4 inhibitor
Chemical Name:
2-[3-[2-(5-Ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid
Molecular Weight:
474.55
Molecular Formula:
C31H26N2O3
Solubility:
Soluble in DMSO (up to at lease 25 mg/ml).
Physical Properties:
Off-white or pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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