BO-264 | TACC3 inhibitor

CAS:
2408648-20-2
Catalog Number:
10-4685
Activity:
TACC3 inhibitor
Chemical Names:
3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine
Molecular Weight:
353.38
Molecular Formula:
C18H19N5O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$65.00
25 mg$240.00

BO-264 (2408648-20-2) is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26.

References:

  1. Akbulut et al. (2020), A Highly Potent TACC3 Inhibitor as a Novel Anticancer Drug Candidate; Mol. Cancer Ther. 19 11243
CAS:
2408648-20-2
Catalog Number:
10-4685
Activity:
TACC3 inhibitor
Chemical Names:
3-(4-Methoxyphenyl)-N-(2-morpholin-4-ylpyrimidin-4-yl)-1,2-oxazol-5-amine
Molecular Weight:
353.38
Molecular Formula:
C18H19N5O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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