Bongkrekic Acid | Inhibits MPT pore opening
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 µg | $160.00 | ||
| 500 µg | $500.00 |
Bongkrekic acid (11076-19-0) is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT).1 Inhibits mitochondrial permeability transition pore opening.2,3 Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells.4
References/Citations:
1) Ziegler et al. (1993), The adenine nucleotide translocase modulates oligomycin-induced quenching of pyranine fluorescence in submitochondrial particles; J. Biol. Chem., 268 25320
2) Marchetti et al. (1996), Mitochondrial permeability transition triggers lymphocyte apoptosis; J. Immunol., 157 4830
3) Zamzami et al. (1996), Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis; FEBS Lett., 384 53
4) Yamada et al. (2013), Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells; J. Pharm. Sci., 102 1008
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Bongkrekic acid (11076-19-0) is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT).1 Inhibits mitochondrial permeability transition pore opening.2,3 Delivery of bongkrekic acid to the mitochondria prevents apoptosis in HeLa cells.4
References/Citations:
1) Ziegler et al. (1993), The adenine nucleotide translocase modulates oligomycin-induced quenching of pyranine fluorescence in submitochondrial particles; J. Biol. Chem., 268 25320
2) Marchetti et al. (1996), Mitochondrial permeability transition triggers lymphocyte apoptosis; J. Immunol., 157 4830
3) Zamzami et al. (1996), Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis; FEBS Lett., 384 53
4) Yamada et al. (2013), Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells; J. Pharm. Sci., 102 1008
Related products
-
Auranofin | IKK inhibitor
$50.00CAS:34031-32-8Catalog Number:10-2373Activity:IKK inhibitorAlternate Names:SKF-39162Chemical Name:1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetateMolecular Weight:678.49Molecular Formula:C20H34AuO9PSSolubility:Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 4 mg/ml).Physical Properties:White solidPurity:98%Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.Shipping Code:RT -
CAPE | Inhibits NFkB activation
From $30.00CAS:104594-70-9Catalog Number:10-2265Activity:Inhibits NFκB activationAlternate Names:Caffeic acid phenethylesterChemical Name:3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl esterMolecular Weight:284.32Molecular Formula:C17H16O4Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
Tyrphostin 9 | PDGFR kinase inhibitor and Oxidative phosphorylation inhibitor
From $30.00CAS:10537-47-0Catalog Number:10-1535Activity:PDGFR kinase inhibitor and OX Phosphorylation inhibitorAlternate Names:Tyrphostin a9, Malonoben, AG-17, SF 6847, RG-50872Chemical Name:3,5-Di-tert-butyl-4-hydroxybenzylidene-malononitrileMolecular Weight:282.38Molecular Formula:C18H22N2OSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)Physical Properties:Orange solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
