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Product Details

BRL-50481 | PDE7 inhibitor

BRL-50481 (433695-36-4) is a potent and selective inhibitor of phosphodiesterase-7 (PDE7), Ki=180 nM.1 Induces apoptosis in chronic lymphocytic leukemia cells which express PDE7B.2 BRL-50481 increases mineralization in osteoblasts differentiated from hMSC.3 Cell permeable.

References/Citations
1) Smith et al. (2004), Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages and CD8+ T-lymphocytes; Mol. Pharmacol., 66 1679
2) Zhang et al. (2008), Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia; Proc. Natl. Acad. Sci. USA 105 19532
3) Pekkinen et al. (2008), Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts; Bone 43 84

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Focus Biomolecules cell signaling reagent supplier, chemical structure of BRL-50481 | PDE7 inhibitor | CAS 433695-36-4

Catalog#  10-1300

$60.00
Quantity
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CAS:
433695-36-4
Catalog Number:
10-1300
Activity:
PDE7 inhibitor
Chemical Name:
3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene
Molecular Weight:
244.27
Molecular Formula:
C9H12N2O4
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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