Bromo-PTC | Cruzain Inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $55.00 | ||
| 50 mg | $220.00 |
Bromo-PTC (443144-54-5) is a potent inhibitor of cruzain (IC50 = 100 nM). Cruzain is the major cysteine protease of Trypanosoma cruzi, the protozoan parasite responsible for American trypanosomiasis or Chagas’ disease. Cruzain is essential for the replication of the parasite and thus is a new target for antitrypanosomal chemotherapy. Bromo-PTC exhibits trypanocidal activity in cultured host cells without toxicity1.
References/Citations:
1) Xaohui et al. (2002), Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain; J. Med. Chem., 45 2695
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Bromo-PTC (443144-54-5) is a potent inhibitor of cruzain (IC50 = 100 nM). Cruzain is the major cysteine protease of Trypanosoma cruzi, the protozoan parasite responsible for American trypanosomiasis or Chagas’ disease. Cruzain is essential for the replication of the parasite and thus is a new target for antitrypanosomal chemotherapy. Bromo-PTC exhibits trypanocidal activity in cultured host cells without toxicity1.
References/Citations:
1) Xaohui et al. (2002), Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain; J. Med. Chem., 45 2695
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