Bromo-PTC | Cruzain Inhibitor

CAS:
443144-54-5
Catalog Number:
10-1433
Activity:
Cruzain Inhibitor
Chemical Name:
3′-Bromopropiophenone thiosemicarbazone
Molecular Weight:
286.2
Molecular Formula:
C10H12BrN3S
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Available Options

size :PriceQuantity 
10 mg$55.00
50 mg$220.00

Bromo-PTC (443144-54-5) is a potent inhibitor of cruzain (IC50 = 100 nM). Cruzain is the major cysteine protease of Trypanosoma cruzi, the protozoan parasite responsible for American trypanosomiasis or Chagas’ disease. Cruzain is essential for the replication of the parasite and thus is a new target for antitrypanosomal chemotherapy. Bromo-PTC exhibits trypanocidal activity in cultured host cells without toxicity1.

References/Citations:

1) Xaohui et al. (2002), Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain; J. Med. Chem., 45 2695

CAS:
443144-54-5
Catalog Number:
10-1433
Activity:
Cruzain Inhibitor
Chemical Name:
3′-Bromopropiophenone thiosemicarbazone
Molecular Weight:
286.2
Molecular Formula:
C10H12BrN3S
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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