BT2 | BCKDC kinase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $175.00 |
BT2 (34576-94-8) is an inhibitor of the mitochondrial branched-chain α-ketoacid dehydrogenase complex kinase (BCKDC) – IC50 = 3.19 µM.1 Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 has also been shown to be a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.2
References/Citations:
1) Tso et al. (2014), Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase; J. Biol. Chem., 289 20583
2) Friberg et al. (2013), Discovery of potent myeloid cell leukemia (Mcl 1) inhibitors using fragment based methods and structure based design; J. Med. Chem. 56 15
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
BT2 (34576-94-8) is an inhibitor of the mitochondrial branched-chain α-ketoacid dehydrogenase complex kinase (BCKDC) – IC50 = 3.19 µM.1 Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo. BT2 has also been shown to be a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.2
References/Citations:
1) Tso et al. (2014), Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase; J. Biol. Chem., 289 20583
2) Friberg et al. (2013), Discovery of potent myeloid cell leukemia (Mcl 1) inhibitors using fragment based methods and structure based design; J. Med. Chem. 56 15
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