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BT2 | BCKDC kinase inhibitor

BT2 (34576-94-8) is an inhibitor of the mitochondrial branched-chain a-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM.1  Inhibition of this kinase has been shown to reduce levels of branched-chain amino acid concentrations in vivo.  BT2 has also been shown to be a moderate inhibitor (Ki = 59 µM) of myeloid cell leukemia 1(Mcl 1), a Bcl-2 family protein.2

References/Citations

1) Tso et al. (2014), Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase; J. Biol. Chem., 289 20583
2) Friberg et al. (2013), Discovery of potent myeloid cell leukemia (Mcl 1) inhibitors using fragment based methods and structure based design; J. Med. Chem. 56 15

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Focus Biomolecules cell signaling reagent supplier, chemical structure of BT2 | BCKDC kinase inhibitor | CAS 34576-94-8

Catalog#  10-4717-0010

$50.00
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CAS:
34576-94-8
Catalog Number:
10-4717
Activity:
BCKDC kinase inhibitor
Chemical Name:
3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid
Molecular Weight:
247.10
Molecular Formula:
C9H4Cl2O2S
Solubility:
Soluble in DMSO (up to at least 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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